Modular Composition of Gene Transcription Networks

Modular Composition of Gene Transcription Networks

Predicting the dynamic behavior of a large network from that of the composing modules is a central problem in systems and synthetic biology. Yet, this predictive ability is still largely missing because modules display context-dependent behavior. One cause of context-dependence is retroactivity, a phenomenon similar to loading that influences in non-trivial ways the dynamic performance of a mod...

Modular structure of transcription factors: implications for gene regulation.

Modular rule base fuzzy networks for linguistic composition based modelling

Modular Composition of Coordination Services

Coordination services like ZooKeeper, etcd, Doozer, and Consul are increasingly used by distributed applications for consistent, reliable, and high-speed coordination. When applications execute in multiple geographic regions, coordination service deployments trade-off between performance, (achieved by using independent services in separate regions), and consistency. We present a system design f...

Modularity in Complex Gene Transcription Networks

A promising approach to decipher the complexity of biomolecular networks is to predict their behavior from that of the composing modules. Unfortunately, the behavior of a module changes once connected in the network [1] due to retroactivity effects. Retroactivity arises whenever two molecules bind describing the effect that these molecules become unavailable for other reactions. Recent experime...